Acetyl tributyl citrate and dibutyl sebacate inhibit the growth of cultured mammalian cells.

Acetyl tributyl citrate (ATBC) and dibutyl sebacate (DBS) plasticizers are components of polyvinylidene chloride. These compounds can pass from the polyvinylidene chloride packing films to the enclosed food (Baba et al. 1988). Therefore, there may be a potential hazard to health. Toxicity of these compounds in laboratory animals is well known (Mallette and Haam 1952; Smith 1953; Finkelstein and Gold 1959). As th in vitro toxicity of these compounds to various mammalian cells, determined using the same cell culture systems has apparently not been documented, we examined the toxicity of ATBC and DBS on human, monkey and dog cells grown in culture systems.